Clinico-pathologic relevance of Survivin splice variant expression in cancer
نویسندگان
چکیده
منابع مشابه
Survivin expression in oesophageal squamous cell carcinoma: its prognostic impact and splice variant expression.
PURPOSE The present study examined the clinicopathological impact of survivin expression in oesophageal squamous cell carcinoma (ESCC). In addition, the biological role of anti-apoptosis parameter in ESCC was examined immunohistochemically. PATIENTS AND METHOD Subjects comprised 71 patients followed up for 5 years after surgery for ESCC and analysed immunohistochemically to examine the clinic...
متن کاملApoptosis gene signature of Survivin and its splice variant expression in breast carcinoma.
Survivin, an anti-apoptotic protein, was described as strongly expressed in human cancers including breast cancer. However, little is known about the association between Survivin variants (Survivin-2B, Survivin-ΔEx3, Survivin-3B, and Survivin-2α) and the other apoptotic-related genes. In this study, we analyzed the apoptosis gene signature of Survivin and its variant expression in breast cancer...
متن کاملExpression of the survivin-2B splice variant related to the progression of colorectal carcinoma
PURPOSE Recently, two alternatively spliced survivin variants, survivin-ΔEx3 and survivin-2B, were identified in a single copy of the survivin gene. It has been reported that the expressions of survivin splice variants significantly correlates with the clinical results in many types of human carcinoma. We investigated the transcription levels of survivin and its splice variants in human colorec...
متن کاملبررسی بیان ژن Survivin و واریانت‌های پیرایشی 2B و ΔEx3 آن به عنوان مارکرهای مولکولی تشخیصی جدید در تومورهای تیروئیدی
Evaluating the Expression of Survivin and Its Splice Variants 2B and ΔEx3 as New Diagnostic Molecular Markers in Thyroid Cancer Vandghanooni S1, Hosseinpour Feizi MA1, Babaei E1,2, Montazeri V3, Halimi M3 1 Dept of Biology, School of Nature Sciences, Tabriz University, Tabriz, Iran 2 Dept of Genetics, Faculty of Basic Sciences, Tarbiat Modarres University, Tehran, Iran 3 Imam Khomeini Hospital,...
متن کاملمطالعهی بیان ژنSurvivin و واریانت‌های پیرایشی ΔEx3٬ 2b و 3b آن به عنوان تومور مارکرهای تشخیصی در سرطان پستان
Introduction: Survivin is a new member of the Inhibitor Apotosis Protein family (IAP) which plays an important role in the regulation of both cell cycle and apoptosis. Its distinct expression in tumor cells as compared to normal adult cells introduces Survivin as the fourth transcriptom demonstrated in tumors. Breast cancer is the most common malignancy among women and scientist`s efforts to cl...
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ژورنال
عنوان ژورنال: Cancer Letters
سال: 2013
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2013.06.007